Insulin signaling

Metabolism

Metabolic disease

Throughout the day, during and between meals, the body must continuously determine:

(1) how much glucose, fat, and cholesterol should be generated or eliminated, and (2) how to transport those molecules between tissues and fluids. Our lab investigates how insulin signaling controls these processes, and how they become disrupted in conditions like insulin resistance, diabetes, liver disease, and atherosclerosis.

We use molecular and cellular approaches, metabolomics, proteomics and phosphoproteomics, RNA sequencing, kinetics using tracers, primary cells and organoids, physiology, mouse models of disease, and human specimens.

#metabolism #cholesterol #bile-acids #lipids #glucose #insulin #diabetes #obesity #atherosclerosis #liver #gut 

A full list of publications can be found at: NCBI, Google Scholar, or ORCID