A full list of publications can be found at: NCBI, Google Scholar, or ORCID
2021-2023
The python-derived 16α-hydroxylated bile acid, pythocholic acid decreases food intake and increases oleoylethanolamide in male miceHiguchi S Wood C, Nasiri RH, Giddla LJ, Molina V, Diarra R, DiPatrizio NV, Kawamura A, Haeusler RA. (2023)Endocrinology
An Updated Perspective on the Dual-Track Model of Enterocyte Fat MetabolismCook JR, Kohan AB, Haeusler RA. (2022) J Lipid Res 63: 100278
Hepatic FoxOs link insulin signaling with plasma lipoprotein metabolism through an apolipoprotein M/sphingosine-1-phosphate pathwayIzquierdo MC, Shanmugarajah N, Lee SX, Kraakman MJ, Westerterp M, Kitamoto T, Harris M, Cook JR, Gusarova GA, Zhong K, Marbuary E, O-Sullivan I, Rasmus NF, Camastra S, Unterman T, Ferrannini E, Hurwitz BE, Haeusler RA (2022)J Clin Invest 132: e146219
Differential effects of bariatric surgery on plasma levels of ANGPTL3 and ANGPTL4Bini S, D’Erasmo L, Astiarraga B, Minicocci I, Palumbo M, Pecce V, Polito L, Di Costanzo A, Haeusler RA, Arca M, Ferrannini E, Camastra S. (2022) Nutr Metab Cardiovasc Dis 32: 2647
Sex-specific differences in metabolic outcomes after sleeve gastrectomy and intermittent fasting in obese middle-aged miceEmiliano AB, Lopatinsky NR, Kraljevic M, Higuchi S, He Y, Haeusler RA, and Schwartz GJ (2022) Am J Physiol Endocrinol Metab 323: E107
FOXO1 is present in stomach epithelium and determines gastric cell distributionMcKimpson WM, Kuo T, Kitamoto T, Higuchi S, Mills JC, Haeusler RA, Accili D. (2022) Gastro Hep Advances 1: 733
Hepatocentric leptin signaling modulates gluconeogenesis via MKP-3Gamarra JR and Haeusler RA (2022) Cell Mol Gastroenterol Hepatol
Cyp2c-deficiency depletes muricholic acids and protects against high fat diet-induced obesity in male mice but promotes liver damageOteng A-B, Higuchi S, Banks AS, Haeusler RA (2021) Mol Metab 53: 101326
2020
Bile acid composition regulates GPR119-dependent intestinal lipid sensing and food intake regulation in miceHiguchi S, Ahmad TR, Argueta DA, Perez PA, Zhao C, Schwartz GJ, DiPatrizio NV, Haeusler RA (2020)Gut 69: 1620-1628
Bile acid composition regulates the manganese transporter Slc30a10 in intestine Ahmad TR, Higuchi S, Bertaggia E, Hung A, Shanmugarajah N, Guilz NC, Gamarra JR, Haeusler RA (2020)J Biol Chem 295: 12545-12558
Fat: who, where, and how.Haeusler RA (2020) Cell Metab 31: 655-657
Insulin stimulated lipogenesis gets an epigenetic makeoverManuel CR and Haeusler RA (2020) J Clin Invest 130: 2809-2810
Inhibition of PU.1 ameliorates metabolic dysfunction and non-alcoholic steatohepatitisLiu Q, Yu J, Wang L, Tang Y, Zhou Q, Ji S, Wang Y, Santos L, Haeusler RA, Que J, Rajvhandari P, Lei X, Valenti L, Pajvani UB, Qin J, Qiang L (2020)J Hepatol 73: 361-370
2019
Bile acids in glucose metabolism and insulin signaling: mechanisms and research needs Ahmad TR and Haeusler RA (2019) Nature Reviews Endocrinology 15: 701-712
Increased apolipoprotein C3 drives cardiovascular risk in type 1 diabetesKanter JE, Shao B, Kramer F, Barnhart S, Shimizu-Albergine M, Vaisar T, Graham MJ, Crooke RM, Manuel CR, Haeusler RA, Mar D, Bomsztyk K, Hokanson JE, Kinney GL, Snell-Bergeon JK, Heinecke JW, Bornfeldt KE (2019)The Journal of Clinical Investigation 130: 4165-4179
Glucose-6-Phosphate Regulates Hepatic Bile Acid Synthesis in MiceHoogerland JA, Lei Y, Wolters JC, deBoer JF, Bos T, Bleeker A, Mulder NL, van Dijk TH, Kuivenhoven JA, Rajas F, Mithieux G, Haeusler RA, Verkade HJ, Bloks VW, Kuipers F, Oosterveer MH (2019)Hepatology 70: 2171-2184
2018
FoxO Transcription Factors are Required for Hepatic HDL-Cholesterol ClearanceLee SX, Heine M, Schlein C, Ramakrishnan R, Liu J, Belnavis G, Haimi I, Fischer AW, Ginsberg HN, Heeren J, Rinninger F, and Haeusler RA (2018)The Journal of Clinical Investigation 128: 1615-1626
Gamma-secretase inhibition lowers plasma triglyceride-rich lipoproteins by stabilizing the LDL receptorKim KJ, Goldberg IJ, Graham MJ, Sundaram M, Bertaggia E, Lee SX, Qiang L, Haeusler RA, Metzger D, Chambon P, Yao Z, Ginsberg HN, and Pajvani UB (2018)Cell Metabolism 27: 816-827
Metformin and AMP Kinase activation increase expression of the sterol transporters ABCG5/8 (ATP-Binding Cassette Transporter G5/G8) with potential antiatherogenic consequencesMolusky MM, Hsieh J, Lee SX, Ramakrishnan R, Tascau L, Haeusler RA, Accili D, Tall AR (2018)Arteriosclerosis, Thrombosis, and Vascular Biology 38: 1493-1503
Unexplained reciprocal regulation of diabetes and lipoproteinsHiguchi S, Izquierdo MC, Haeusler RA (2018)Current Opinion in Lipidology 29: 186-193
Biochemical and cellular properties of insulin receptor signalingHaeusler RA, McGraw TE, Accili D (2018)Nature Reviews Molecular Cell Biology 19: 31-44
microRNA-205-5p is a modulator of insulin sensitivity that inhibits FOXO function Langlet F, Tarbier M, Haeusler RA, Camastra S, Ferrannini E, Friedlander MR, and Accili D (2018)Molecular Metabolism 17: 49-60
2016-2017
Selective Inhibition of FOXO1 Activator/Repressor Balance Modulates Hepatic Glucose HandlingLanglet, Haeusler RA, Linden D, Ericson E, Norris T, Johansson A, Cook JR, Aizawa K, Sang L, Buettner C, Accili D (2017) Cell 171: 824-835
Cyp8b1 ablation prevents western diet-induced weight gain and hepatic steatosis because of impaired fat absorptionBertaggia E, Jensen KK, Castro-Perez J, Xu Y, Di Paolo G, Chan RB, Wang L, Haeusler RA (2017) American Journal of Physiology – Endocrinology & Metabolism 313: E121-E133
Increased Bile Acid Synthesis and Impaired Bile Acid Transport in Human ObesityHaeusler RA, Camastra S, Nannipieri M, Astiarraga G, Castro-Perez J, Xie D, Wang L, Chakravarthy M, Ferrannini E (2016) Journal of Clinical Endocrinology & Metabolism 101: 1935-1944
2014-2015
Increased Bile Acid Synthesis and Deconjugation after Biliopancreatic DiversionFerrannini E, Camastra S, Astiarraga G, Nannipieri M, Castro-Perez J, Xie D, Wang L, Chakravarthy M, Haeusler RA (2015)Diabetes 64: 3377-3385
Temporal changes in bile acid levels and 12-hydroxylation after Roux-en-Y gastric bypass surgery in type 2 diabetesDutia R, Embrey M, O’Brien C, Haeusler RA, Agenor K, Homel P, McGinty J, Vincent R, Alaghband-Zadeh J, Staels B, Le Roux C, Yu J, and Laferrere B (2015)International Journal of Obesity 39: 806-813
Decreased Expression of Hepatic Glucokinase in Type 2 DiabetesHaeusler RA, Camastra S, Astiarraga B, Nannipieri M, Anselmino N, and Ferranini E (2014)Molecular Metabolism 4: 222-226
Integrated control of hepatic lipogenesis versus glucose production requires FoxO transcription factorsHaeusler RA, Hartil K, Vaitheesvaran B, Arrieta-Cruz I, Knight CM, Cook JR, Kammoun HL, Febbraio MA, Gutierrez-Juarez R, Kurland IJ, and Accili D (2014)Nature Communications 5: 5190
2012-2013
Human Insulin Resistance is Associated with Increased Plasma Levels of 12-Hydroxylated Bile AcidsHaeusler RA, Astiarraga B, Camastra S, Accili D, and Ferrannini E (2013) Diabetes 62: 4184-91
Mod5 protein binds to tRNA gene complexes and affects local transcriptional silencingPratt-Hyatt M, Pai DA, Haeusler RA, Wozniak GG, Good PD, Miller EL, McLeod IX, Yates JR 3rd, Hopper AK, and Engelke DR (2013)PNAS 110: E3081-9
Impaired Generation of 12-Hydroxylated Bile Acids Links Hepatic Insulin Signaling with DyslipidemiaHaeusler RA, Pratt-Hyatt M, Welch CL, Klaassen CD, and Accili D (2012)Cell Metabolism 15: 65-74
Regulation of hepatic LDL receptors by mTORC1 and PCSK9Ai D, Chen C, Han S, Ganda A, Murphy AJ, Haeusler R, Thorp E, Accili D, Horton JD, and Tall AR (2012)The Journal of Clinical Investigation 122: 1262-1270
2010-2011
Dissociation of the Glucose and Lipid Regulatory Functions of FoxO1 by Targeted Knockin of Acetylation-Defective Alleles in Mice Banks AS, Kim-Muller JY, Mastracci TL, Kofler NM, Qiang L, Haeusler RA, Jurczak MJ, Laznik D, Heinrich G, Samuel VT, Shulman GI, Papaioannou VE, and Accili D (2011)Cell Metabolism 14: 587-597
FoxOs function synergistically to promote glucose productionHaeusler RA, Kaestner KH, and Accili D (2010)Journal of Biological Chemistry 285: 35245-35248
Hepatic FoxO1 ablation exacerbates lipid abnormalities during hyperglycemiaHaeusler RA, Han S, and Accili D (2010)Journal of Biological Chemistry 285: 26861-26868